SARS — beginning to understand a new virus
Identifieur interne : 005E52 ( Main/Exploration ); précédent : 005E51; suivant : 005E53SARS — beginning to understand a new virus
Auteurs : Konrad Stadler [Italie] ; Vega Masignani [Italie] ; Markus Eickmann [Allemagne] ; Stephan Becker [Allemagne] ; Sergio Abrignani [Italie] ; Hans-Dieter Klenk [Allemagne] ; Rino Rappuoli [Italie]Source :
- Nature Reviews. Microbiology [ 1740-1526 ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux, Génome viral, Génomique, Humains, Phylogénie, Protéines virales (génétique), Protéines virales (métabolisme), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- génétique : Protéines virales, Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère.
- métabolisme : Protéines virales.
- physiologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Génome viral, Génomique, Humains, Phylogénie, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Genome, Viral, Genomics, Humans, Phylogeny, SARS Virus (classification), SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Proteins.
- classification : SARS Virus.
- genetics : SARS Virus.
- immunology : Severe Acute Respiratory Syndrome.
- chemical , metabolism : Viral Proteins.
- physiology : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Genome, Viral, Genomics, Humans, Phylogeny.
Abstract
A new infectious disease, called severe acute respiratory syndrome (SARS), appeared in southern China in 2002. During the period from November 2002 to the summer of 2003, the World Health Organization recorded 8098 probable SARS cases and 774 deaths in 29 countries. A previously unknown coronavirus was isolated from FRhK-4 and Vero E6 cells inoculated with clinical specimens from patients. A virus with close homology to SARS-CoV was isolated from palm civets and racoon dogs, which are used as food in southern China In less than a month from the first indication that a coronavirus might be implicated in the disease, the nucleotide sequence of the virus was available, and diagnostic tests were set up. The phylogenetic analysis of the SARS-CoV genome revealed that the virus is distinct from the three known groups of coronaviruses and represents an early split-off from group 2. The development of antiviral drugs or vaccines is being investigated. Viral enzymes essential for virus replication, such as the RNA-dependent RNA polymerase (RdRp), the 3C-like cystein protease (3Clpro) and the helicases are the most attractive targets for antiviral molecules. Of the possible vaccine targets, the spike (S) protein represents the most promising one. So far, β-interferon is the only licensed drug available, which has been reported to interfere with virus replication
Url:
DOI: 10.1038/nrmicro775
PubMed: 15035025
PubMed Central: 7097337
Affiliations:
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Le document en format XML
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Microbiology</title><idno type="ISSN">1740-1526</idno><idno type="eISSN">1740-1534</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Genome, Viral</term><term>Genomics</term><term>Humans</term><term>Phylogeny</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Génome viral</term><term>Génomique</term><term>Humains</term><term>Phylogénie</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genome, Viral</term><term>Genomics</term><term>Humans</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Génome viral</term><term>Génomique</term><term>Humains</term><term>Phylogénie</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p id="Par7"><list list-type="bullet"><list-item><p id="Par8">A new infectious disease, called severe acute respiratory syndrome (SARS), appeared in southern China in 2002. During the period from November 2002 to the summer of 2003, the World Health Organization recorded 8098 probable SARS cases and 774 deaths in 29 countries.</p></list-item><list-item><p id="Par9">A previously unknown coronavirus was isolated from FRhK-4 and Vero E6 cells inoculated with clinical specimens from patients. A virus with close homology to SARS-CoV was isolated from palm civets and racoon dogs, which are used as food in southern China</p></list-item><list-item><p id="Par10">In less than a month from the first indication that a coronavirus might be implicated in the disease, the nucleotide sequence of the virus was available, and diagnostic tests were set up.</p></list-item><list-item><p id="Par11">The phylogenetic analysis of the SARS-CoV genome revealed that the virus is distinct from the three known groups of coronaviruses and represents an early split-off from group 2.</p></list-item><list-item><p id="Par12">The development of antiviral drugs or vaccines is being investigated. Viral enzymes essential for virus replication, such as the RNA-dependent RNA polymerase (RdRp), the 3C-like cystein protease (3Clpro) and the helicases are the most attractive targets for antiviral molecules. Of the possible vaccine targets, the spike (S) protein represents the most promising one.</p></list-item><list-item><p id="Par13">So far, β-interferon is the only licensed drug available, which has been reported to interfere with virus replication <italic>in vitro</italic>. Should SARS return during the next winter, we will still need to rely mostly on quarantine measures to contain it.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hon, Kl" uniqKey="Hon K">KL Hon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG 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uniqKey="Rottier P">PJM Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Xj" uniqKey="Yu X">XJ Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tresnan, Db" uniqKey="Tresnan D">DB Tresnan</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Zelus, Bd" uniqKey="Zelus B">BD Zelus</name></author><author><name sortKey="Schickli, Jh" uniqKey="Schickli J">JH Schickli</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Van Der Zee, R" uniqKey="Van Der Zee R">R van der Zee</name></author><author><name sortKey="De Haan, Cam" uniqKey="De Haan 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Leparc-Goffart</name></author><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author><author><name sortKey="Tsai, Jc" uniqKey="Tsai J">JC Tsai</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stauber, R" uniqKey="Stauber R">R Stauber</name></author><author><name sortKey="Pfleiderera, M" uniqKey="Pfleiderera M">M Pfleiderera</name></author><author><name sortKey="Siddell, S" uniqKey="Siddell S">S Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, Cw" uniqKey="Olsen C">CW Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saitou, N" uniqKey="Saitou N">N Saitou</name></author><author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Stadler, Konrad" sort="Stadler, Konrad" uniqKey="Stadler K" first="Konrad" last="Stadler">Konrad Stadler</name></noRegion><name sortKey="Abrignani, Sergio" sort="Abrignani, Sergio" uniqKey="Abrignani S" first="Sergio" last="Abrignani">Sergio Abrignani</name><name sortKey="Masignani, Vega" sort="Masignani, Vega" uniqKey="Masignani V" first="Vega" last="Masignani">Vega Masignani</name><name sortKey="Rappuoli, Rino" sort="Rappuoli, Rino" uniqKey="Rappuoli R" first="Rino" last="Rappuoli">Rino Rappuoli</name></country><country name="Allemagne"><noRegion><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name></noRegion><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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